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A perfectly baked meatloaf casserole slice with a crispy, golden cheese crust and juicy, seasoned ground beef layers. The focus keyword enhances the rich, comforting appeal of this delicious homemade dish.

The Ultimate Meatloaf Casserole

Calista
A cozy, layered meatloaf casserole packed with succulent ground meat, tangy sauce, and bubbling cheese—an easy way to enjoy classic comfort food any night of the week.
Prep Time 15 minutes
Cook Time 35 minutes
Total Time 50 minutes
Course Main Course
Cuisine American
Servings 6
Calories 380 kcal

Equipment

  • 9x13-inch baking dish
  • Large mixing bowl
  • Measuring cups/spoons
  • Oven preheated to 350°F (175°C)
  • Optional skillet for sautéing veggies

Ingredients
  

  • 2 pounds ground beef or turkey
  • 1 small onion finely chopped
  • ½ cup breadcrumbs or panko
  • 2 large eggs
  • 1 cup tomato sauce or ketchup divided
  • 1 teaspoon salt
  • ½ teaspoon black pepper
  • ½ teaspoon garlic powder
  • 1 –2 cups shredded cheese e.g., cheddar, mozzarella

(Optional) Chopped veggies (bell peppers, spinach), thinly sliced potatoes, or tater tots

Instructions
 

  • Preheat oven to 350°F (175°C). Grease a 9x13-inch baking dish.
  • In a large bowl, gently mix ground meat, onion, breadcrumbs, eggs, half the tomato sauce (or ketchup), and seasonings.
  • Press the meat mixture into the greased dish, creating an even layer.
  • Spread remaining sauce over the meat. Top with cheese (and optional add-ons like tater tots or potato slices).
  • Bake for 30–35 minutes, or until the internal temperature reaches 160°F (71°C).
  • Let it rest for 5 minutes before slicing and serving.

Notes

For the juiciest results, aim for a balanced meat blend (about 85% lean) and allow the casserole to rest for a few minutes after baking before slicing.
Keyword meatloaf casserole